Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil.

نویسندگان

  • H Akari
  • Y Yamamoto
  • H Hiwada
  • Y Saito
  • N Takayanagi
  • A H Koyama
  • A Adachi
چکیده

Fasudil is a potent inhibitor for various protein kinases such as myosin light chain kinase and protein kinase C. It has been used as a drug for improvement of intracranial vasospasm and following ischaemic diseases. In this report, we demonstrate that fasudil suppressed the replication of human immunodeficiency virus type 1 (HIV-1) in mitogen-activated peripheral blood mononuclear cells. Our finding shows that fasudil may be useful as a new and distinct chemotherapeutic agent against HIV-1 infection.

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عنوان ژورنال:
  • The journal of medical investigation : JMI

دوره 44 3-4  شماره 

صفحات  -

تاریخ انتشار 1998